PNH and the GPI-Linked Proteins

By Neal S. Young

Subjects: Hemoglobinopathies, Hemoglobinopathy, Glycoproteins, Phosphoinositides, Glycosylphosphatidylinositols, Cellular signal transduction, Paroxysmal Hemoglobinuria, Paroxysmal hemoglobinuria, Membrane proteins

Description: Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mec.